The effect of fatigue on the cognitive status and quality of life of patients with Lyme- borreliosis
No 2 (2023), Research
No 2 (2023)

The effect of fatigue on the cognitive status and quality of life of patients with Lyme- borreliosis

Research
https://doi.org/10.31612/2616-4868.2(24).2023.09
Published June 5, 2023
T. Yu. Malysh
Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
http://orcid.org/0000-0002-6930-6521
M.A. Trishchynska
Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
http://orcid.org/0000-0002-1022-0635
ARTICLE PDF (Українська)

Keywords

Lyme-borreliosis
quality of life
cognitive disorders
fatigue

How to Cite

Malysh, T. Y., & Trishchynska, M. (2023). The effect of fatigue on the cognitive status and quality of life of patients with Lyme- borreliosis. Clinical and Preventive Medicine, (2), 61-67. https://doi.org/10.31612/2616-4868.2(24).2023.09
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Abstract

 The relevance of the issue of asthenic disorders is determined by a high prevalence among patients with various chronic pathologies and its impact on the disease course, treatment efficacy, and quality of life. The purpose of the study was to analyze the dependence of cognitive disorders and the quality of life of patients with Lyme borreliosis on the level of fatigue.

Materials and Methods. The study involved 48 patients with Lyme borreliosis. The MOS 36-item Short Form Health Survey (SF-36) was used to study the quality of life of patients. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), and the impact of fatigue was evaluated using the Fatigue Severity Scale (FSS).

Results. According to the results of assessing asthenia/fatigue severity (FSS), the prevalence of asthenic disorders in patients with Lyme borreliosis was 45.8%. Cognitive impairment with an MMSE score of <28 was found in 64.6% of patients, and the MoCA score of <26 was revealed in 56.2% of patients. Manifestations of moderate or severe fatigue were more common among women (OR 5.43; 95% CI [1,29-22,94]), patients with neuroborreliosis (OR 13.64; 95% CI [2,62-70,9]), patients with late-stage of disease (OR 9.23; 95% CI [2,46-34,58]), and those with a lower MMSE score (26.14±2.53 vs. 27.54±2.25 scores, р=0.048) and MoCA score (23.59±2.77 vs. 25.46±2.42 scores, р=0.016). Fatigue significantly reduces the quality of life of patients with Lyme-borreliosis, in particular: physical functioning (p=0.002), role physical and role emotional (p<0.001), bodily pain (p=0.037), vitality (p<0.001), social functioning (p=0.048).

Conclusions. It was found that the presence of asthenia depends on the gender (female), the presence of clinical manifestations of damage to the nervous system (neuroborreliosis) and cognitive disorders, as well as the late stage of the disease. The presence of fatigue significantly reduces the quality of life of patients with Lyme borreliosis.

https://doi.org/10.31612/2616-4868.2(24).2023.09
ARTICLE PDF (Українська)

References

Klius, V. Ju. (2017). Polyorganic injury in case of Lyme disease. Actual Infectology. 5(5), 256-259. https://doi:10.22141/2312-413x.5.5.2017.121642

Shostakovych-Koretska, L. R., Budayeva, І. V., Cherginets, А. V., Mavrutenkov, V. V., Marchenko, N. Ye. (2014). Lyme borreliosis: diagnosis and treatment issues. Actual Infectology. 2(3), 34-38.

Sykes, R. A., Makiello, P. (2017). An estimate of Lyme borreliosis incidence in Western Europe. J Public Health Oxf Engl. 39(1), 74-81. https://doi: 10.1093/pubmed/fdw017.

Furik, O. O., Rjabokon', O. V., Zadiraka, D. A., Saveliev, V. H., Pak K. A. (2021). Clinical features of Lyme borreliosis in the Zaporizhzhia region for the period of 2015–2019. Actual Infectology. 9(1), 89.

Іllyash, T. І. (2018). Diagnostic problems of neuroborreliosis. Ukrainian Neurological Journal. 2, 5-10. https://doi.org/10.30978/UNZ201825

Wormser, G. P., Sudhindra, P., Lopez, E., Patel, L., Rezai, S., & Visintainer, P. (2016). Fatigue in patients with erythema migrans. Diagn Microbiol Infect Dis. 86(3), 322-326. https://doi: 10.1016/j.diagmicrobio.2016.07.026.

Thortveit, E. T., Lorentzen, Å. R., Ljøstad, U., Mygland, Å. (2019). Somatic symptoms and fatigue in a Norwegian population with high exposure to ticks. Ticks Tick-Borne Dis. 10(1), 156-161. https://doi: 10.1016/j.ttbdis.2018.09.012.

Este´vez-Lo´pez, F., Mudie, K., Wang-Steverding, X., Bakken, I. J., Ivanovs, A., & Lacerda E. (2020). Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology. J Clin Med. 9(5), 1557. https://doi: 10.3390/jcm9051557.

Pheby, D. F. H., Araja, D., Berkis, U., Brenna, E., Cullinan, J., & Wang-Steverding X. (2020). The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE). Healthc Basel Switz. 8(2), 88. https://doi: 10.3390/healthcare8020088.

Folstein, M. F., Folstein, S. E., McHugh, P. R. (1875). «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12(3). 189-198. https://doi: 10.1016/0022-3956(75)90026-6.

Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., & Chertkow H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 53(4), 695-9. https://doi: 10.1111/j.1532-5415.2005.53221.x.

Jason, L. A., Evans, M., Brown, M., Porter, N., Brown, A., & Lerch A. (2011). Fatigue Scales and Chronic Fatigue Syndrome: Issues of Sensitivity and Specificity. Disabil Stud Q. 31(1). 1375.

Ware, J. (1992). The MOS 36-item short-form healthy survey (SF-36). Medical Care. 30(6), 473-483.

Lantos, P. M., Rumbaugh, J., Bockenstedt, L. K., Falck-Ytter, Y. T., Zemel, L. S. (2020). Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care Res (Hoboken). 73(1), 1-9. https://doi: 10.1002/acr.24495.

Putilina, M. V. (2013). Asthenic disorders in general medical practice. Algorithms for diagnosis and therapy. Nervous diseases. 4, 26-33.

Sigurdardottir, A. H., Knudtzen, F. C., Nymark, A., Bang, M. (2022). Fatigue and cognitive impairment in neuroborreliosis patients posttreatment-A neuropsychological retrospective cohort study. Brain Behav. 12(9), 2719. https://doi: 10.1002/brb3.2719.

Eikeland, R., Ljøstad, U., Mygland, Å., Herlofson, K., Løhaugen, G. (2012). European neuroborreliosis: Neuropsychological findings 30 months post‐treatment. European Journal of Neurology. 19(3), 480-487. https://doi: 10.1111/j.1468-1331.2011.03563.x.

Straub, R. K., Powers, C. M. (2021). Chronic Fatigue Syndrome: A Case Report Highlighting Diagnosing and Treatment Challenges and the Possibility of Jarisch-Herxheimer Reactions If High Infectious Loads Are Present. Healthcare (Basel). 19(11), 1537. https://doi: 10.3390/healthcare9111537.

Knudtzen, F. C., Andersen, N. S., Jensen, T. G., Skarphédinsson, S. (2017). Characteristics and clinical outcome of Lyme neuroborreliosis in a high endemic area, 1995–2014: A retrospective cohort study in Denmark. Clinical Infectious Diseases. 65(9), 1489-1495. https://doi: 10.1093/cid/cix568.

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