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population immunity, diphtheria, vaccination, antibody concentration

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Revenko, G. O., Budayeva, I. V., & Mavrutenkov, V. V. (2019). SEROLOGICAL MONITORING OF POPULATION ANTITOXIC ANTI-DIPHTHERIA IMMUNITY IN RESIDENTS OF DNIPROPETROVSK REGION. Clinical and Preventive Medicine, (3-4), 128-133.


The goal of the work – to present the analysis of epidemiological monitoring of anti-diphtheria protection of the population of Dnepropetrovsk region, to show the generalizing epidemiological situation of diphtheria, to substantiate the need for the development of tools to improve vaccination and to prove the feasibility of regular epidemiology.

Material and methods. Epidemiological analysis of anti-diphtheria immunity (2016-2017) was performed on the basis of the results of the enzyme-linked immunosorbent assay of antibody-IgG against diphtheria toxin (RIDASCREEN Diphtherie IgG (Germany)) in 185 residents of the age from 1 year to 60 years, from them 166 people were included into representative group.

Results. An analysis of the results revealed that only 34.05% (n =63) of the population have antitoxic antibody titers of 1.0 IU/ml or more, providing these residents with adequate protection against diphtheria in the next 5-7 years of life. , most of the population (65.95%) requires immediate single booster vaccination (n=91; 49.19%) or immediate baseline vaccination (n=31; 16.76%). Overall, the results suggest that if diphtheria may occur in country: the disease is likely to be epidemiological or epidemic in nature, as 66% (n=122) of the population do not have sufficient immunological anti-diphtheria protection and require immediate baseline or booster vaccination; children under 15 years of age and adults over 27 will be the most vulnerable to diphtheria.

Conclusions. There are the need to develop strategic measures for mass vaccination of the population (children and adults) against diphtheria, mechanisms for government control over the effectiveness of vaccination, mechanisms of civil or legal liability for voluntary refusal of vaccination without medical indications. It is appropriate and necessary to conduct regular epidemiological monitoring of the intensity of post-vaccination protection of the population against vaccine-preventable infections, in general, including diphtheria.
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