The prognostic value of the certain blood biochemical parameters on the complications in patients with acute coronary syndrome
ARTICLE PDF (Українська)

Keywords

biochemical parameters, acute coronary syndrome, thrombosis, rhythm disturbances

How to Cite

Benkovska, L. K., Mishcheniuk, O. Y., & Kostiukevych, O. M. (2018). The prognostic value of the certain blood biochemical parameters on the complications in patients with acute coronary syndrome. Clinical and Preventive Medicine, (2-3), 63-70. https://doi.org/10.31612/2616-4868.2-5.2018.07

Abstract

Objective. The aim of this study is to determine the features of the course of acute coronary syndrome (ACS), depending on the deviations of individual biochemical parameters in the blood of patients.

Material and methods. Results of biochemical parameters of 59 patients with the ACS, who were treated in the State scientific institution "Scientific-practical center of preventive and clinical medicine" of the State administration (2014-2017 y.), were analyzed. Methods: general clinical, biochemical, statistical.

Abstract. The higher value of low-density lipoprotein (LDL) (2.61±1.05 versus 2.23±1.01; p = 0.047) and gamma-glutamate transferase (GGTP) (39.50±16.45 versus 26.83±6.24; p = 0.036) is observed at the time of verification of ACS, than after one month of its therapy. The level of creatinine > 112 μmol / l (the area under the ROC curve (AUC) = 0.90; p = 0.0001) and urea > 6.3 μmol / l (AUC = 0.90; p = 0.0001) is the “excellent” predictor for rhythm disturbances (RD) in ACS. In ACS patients with creatinine > 112.0 μmol / l (16 of 17 versus 0 of 42; p ˂ 0.0001) and urea > 6.3 μmol / l (12 of 17 versus 4 of 42; р< 0.0001), than in patients with the lower its level, the episodes of RD are observed more commonly and their risk increased by 28.47 times (95 % CI = 5.89-137.52) and 6.45 times (95 % CI = 2.69 -15.41) respectively. The “good” efficacy predictor of the cardiovascular events (CVE) repeated was the level of LDL > 3.4 μmol / l (AUC = 0.72; p = 0.039). The prevalence of patients with multiple CVE was observed in the cohort with LDL value > 3.4 μmol / l (6 of 8 versus 2 of 19 people; p = 0.002), than in the group with the lower level of LDL. In ACS patients the risk of recurrence episode is 7.12 (95 % CI = 1.80-28.05), subject of availability of LDL > 3.4 μmol / l.

Conclusions. The predictors of rhythm disturbances in acute coronary syndrome include the level of creatinine> 112 μmol / l and urea > 6.3 μmol / l. The probability of recurrent cardiovascular events were increased in case of presence LPNP > 3.4 μmol / l in the ACS patients biochemical blood test.

https://doi.org/10.31612/2616-4868.2-5.2018.07
ARTICLE PDF (Українська)

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