Impact of anemia on the clinical course of acute coronary syndrome
ARTICLE PDF (Українська)

Keywords

anemia, acute coronary syndrome, re-thrombosis, hemorrhagic complications

How to Cite

Kostiukevych, O. M., Mishcheniuk, O. Y., & Benkovska, L. K. (2018). Impact of anemia on the clinical course of acute coronary syndrome. Clinical and Preventive Medicine, (2-3), 71-77. https://doi.org/10.31612/2616-4868.2-5.2018.08

Abstract

Objective. The contribution of the anemia on the acute coronary syndrome (ACS) course and complications of there.

Material and methods. Results of clinical and clinic-laboratory parameters of 59 patients with the ACS, who were treated in the State scientific institution "Scientific-practical center of preventive and clinical medicine" of the State administration (2016-2017 y.), were analyzed. Methods: general clinical, laboratorial, statistical.

Results. In 20.93 % (9 persons) patients without the anemia syndrome (AS) at the time of hospitalization (43 persons) the nosocomial anemia had developed. In 77.77 % (7 of 9 people) cases of the incidence of the increasing of the nosocomial AS in the ACS patients due to hemorrhagic complications, the etiology of new 22.23 % (2 out of 9 persons) AS episodes was not defined. The predictor with the “good level” of the efficacy (p=0.003) for the development of the AS during hospitalization is the age of over 75 years, which increases the risk of anemia by 3.80 times (95 CI 1.57-19.18). Patients with the ACS and the hypochromic and normochromic anemia (50.00% and 100% respectively), than patients without it (14.28% vs. 17.54% respectively), were more likely to have hemorrhagic events (5 of 10 versus 7 of 49; p = 0.022 and 2 of 2 versus 10 of 57; p=0.038 respectively). Subject to availability at the time of the ACS occurrence of the hypochromic anemia, the risk of developing hemorrhagic events in therapy is 3.19 (95 % CI 1.35-11.36). The prevalence of re-thromboses is higher in the ACS patients with the anemia, than in patients without it (7 of 16 (43.75 %) versus 3 of 43 (6.97%) persons; p=0.002). The risk of the thrombotic episodes recurrence in ACS patients with the anemia in 3.81 times (95% CI 1.86-7.80) higher, than in persons without it.

Conclusions. The age over 75 years in ACS patients is the predictor of the AS development. In ACS the hypochromic and normochromic anemia increases the incidence of hemorrhagic events. In addition, the anemia in patients with the ACS is the factor of the thrombotic episode recurrent.

https://doi.org/10.31612/2616-4868.2-5.2018.08
ARTICLE PDF (Українська)

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