SENSITIZATION TO MOLECULAR COMPONENTS OF MALASSEZIA ALLERGENS IN CHILDREN WITH ATOPY
ARTICLE PDF (Українська)

Keywords

Malassezia
ALEX
atopy
children

How to Cite

Mozyrska, O. (2022). SENSITIZATION TO MOLECULAR COMPONENTS OF MALASSEZIA ALLERGENS IN CHILDREN WITH ATOPY. Clinical and Preventive Medicine, (2), 36-41. https://doi.org/10.31612/2616-4868.2(20).2022.04

Abstract

The aim

Violation of the epidermal barrier can lead to percutaneous sensitization to microbial products or allergens. The interaction between the yeast Malassezia and the skin's immune system contributes to skin inflammation in patients with atopic dermatitis. The aim of this study was to determine the sensitization to the molecular components of the yeast Malassezia (Mala s 5, Mala s 6, Mala s 11) in children with atopy.

Methods

The study included 333 children aged 1 to 18 with atopy, with symptoms of bronchial obstruction, allergic rhinitis, atopic dermatitis or urticaria. All patients / parents gave informed consent to participate. Spearman's rank test (ρ) was used to assess the correlation between total sIgE, specific sIgE, and age.

Results

Among 333 children with atopy, specific IgE to Mala s 5 was detected in 20.1 % children, to Mala s 6 in 64.6 %, and to the allergen Mala s 11 in 23.1 % children. The level of antibodies to Mala s 5 and Mala s 6 correlate with total serum IgE (ρ = 0.161 and ρ = 0.112, respectively). The correlation was also found between the level of specific IgE to Mala s 11 and to Mala s 6 (ρ = -0.351), and Mala s 5 and Mala s 6 (ρ = -0.490). Correlation of specific IgE and age was detected for the molecular component Mala s 6 (ρ = -0.126).

Conclusions

Sensitization to the molecular components of yeast (Mala s 5, Mala s 6, Mala s 11) was quite common among children with allergic diseases. Sensitization to Mala s 6 was most common in children. The highest values of sIgE were observed for Mala s 11 ‒ in 23.9% of patients. For future clinical trials, it is important to consider intrapersonal anatomical variations in skin microbiota, individual susceptibility, sex, age, seasonality, and ethnicity.

https://doi.org/10.31612/2616-4868.2(20).2022.04
ARTICLE PDF (Українська)

References

Volosovets, О.P., Beketova, G.V., Berezenko, V.S., Mityuryaeva, I.A., Volosovets, T.N., Pochinok, T.V. (2021). Dynamika zabolevaiemosti i raspostranyonnosti atopicheskogo dermatita u detei Ukrainy za posledniie 20 let: mediko-ekologicheskiie aspekty [Dynamics of morbidity and prevalence of atopic dermatitis in children of Ukraine over the past 20 years: medical and environmental aspects]. Pediatriia. Eastern Europe, (2), 206-216. DOI: 10.34883/PI.2021.9.2.005. [in Russian].

Volosovets, О.P., Bolbot, Yu.K., Beketova, G.V., et al. (2021). Alergichnui marsh u ditei Ukrainy [Allergic march in children of Ukraine]. Medical perspectives, 26(4),181-188. doi.org/10.26641/2307-0404.2021.4.248227

Yang, G., Seok, J. K., Kang, H. C., Cho, Y. Y., Lee, H. S., & Lee, J. Y. (2020). Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis. International journal of molecular sciences, 21(8), 2867. https://doi.org/10.3390/ijms21082867

Vijaya Chandra, S. H., Srinivas, R., Dawson, T. L., Jr, & Common, J. E. (2021). Cutaneous Malassezia: Commensal, Pathogen, or Protector?. Frontiers in cellular and infection microbiology, 10, 614446. https://doi.org/10.3389/fcimb.2020.614446

Saunte, D., Gaitanis, G., & Hay, R. J. (2020). Malassezia-Associated Skin Diseases, the Use of Diagnostics and Treatment. Frontiers in cellular and infection microbiology, 10, 112. https://doi.org/10.3389/fcimb.2020.00112

Scheynius, A., Johansson, C., Buentke, E., Zargari, A., & Linder, M. T. (2002). Atopic eczema/dermatitis syndrome and Malassezia. International archives of allergy and immunology, 127(3), 161–169. https://doi.org/10.1159/000053860

Kohsaka, T., Hiragun, T., Ishii, K., Hiragun, M., Kamegashira, A., & Hide, M. (2018). Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis. Allergology international : official journal of the Japanese Society of Allergology, 67(1), 103–108. https://doi.org/10.1016/j.alit.2017.05.009

Mittermann, I., Wikberg, G., Johansson, C., Lupinek, C., Lundeberg, L., Crameri, R., Valenta, R., & Scheynius, A. (2016). IgE Sensitization Profiles Differ between Adult Patients with Severe and Moderate Atopic Dermatitis. PloS one, 11(5), e0156077. https://doi.org/10.1371/journal.pone.0156077

Balaji, H., Heratizadeh, A., Wichmann, K., Niebuhr, M., Crameri, R., Scheynius, A., & Werfel, T. (2011). Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. The Journal of allergy and clinical immunology, 128(1), 92–99.e4. https://doi.org/10.1016/j.jaci.2011.02.043

Heffler, E., Puggioni, F., Peveri, S., Montagni, M., Canonica, G. W., & Melioli, G. (2018). Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis. The World Allergy Organization journal, 11(1), 7. https://doi.org/10.1186/s40413-018-0186-3

Celakovska, J., Vankova, R., Bukac, J., Cermakova, E., Andrys, C., & Krejsek, J. (2021). Atopic Dermatitis and Sensitisation to Molecular Components of Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia-Results of Allergy Explorer ALEX 2. Journal of fungi (Basel, Switzerland), 7(3), 183. https://doi.org/10.3390/jof7030183

Glatz, M., Buchner, M., von Bartenwerffer, W., Schmid-Grendelmeier, P., Worm, M., Hedderich, J., & Fölster-Holst, R. (2015). Malassezia spp.-specific immunoglobulin E level is a marker for severity of atopic dermatitis in adults. Acta dermato-venereologica, 95(2), 191–196. https://doi.org/10.2340/00015555-1864

Brodská, P., Panzner, P., Pizinger, K., & Schmid-Grendelmeier, P. (2014). IgE-mediated sensitization to malassezia in atopic dermatitis: more common in male patients and in head and neck type. Dermatitis: contact, atopic, occupational, drug, 25(3), 120–126. https://doi.org/10.1097/DER.0000000000000040

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.