body mass index
anxiety disorders

How to Cite

Vorokhta, Y. M., & Bieliaieva, N. V. (2023). STRUCTURE OF ANXIETY DISORDERS IN PATIENTS WITH CHRONIC MIGRAINE AND ABDOMINAL OBESITY. Clinical and Preventive Medicine, (8), 52-58.


Introduction. In Ukraine, on average, 30% of people are obese and 25% are overweight. In parallel with the increase in the number of overweight patients, the percentage of people with migraine is increasing. The prevalence of migraine is high, it affects 12-15% of the population. Both diseases negatively affect not only the function of internal organs, but also the nervous-psychological state of patients, leading to anxiety and depressive disorders.

The aim of the study was to analyze the features of the structure of anxiety disorders in obese patients with chronic migraine.

Materials and methods: 180 patients (90 women and 90 men) were examined and divided into two clinical groups: 1st group – 60 persons with chronic migraine with an average BMI=23.5.8±1.10 kg/m2; 2nd group – 60 obese patients with chronic migraine, BMI=34.6±1.42 kg/m2. The control group consisted of 60 patients without a headache and with averange BMI=19.5±0.7 kg/m2. The ICHD-3 criteria were used to diagnose migraine. The DSM-5 criteria were used to diagnose anxiety disorders. The patient's level of anxiety was measured using Taylor Manifest Anxiety Scale (TMAS). Statistical processing was performed using dispersion and correlation analysis.

Results: Phobic anxiety disorders were in 1.5 times more common in 2nd group patients (c2=9.81, p<0.001) than in 1st group patients; panic disorder was in 1.8 times more frequent in 2nd group (c2= 11.99, p<0.001) than in the 1st group, generalized anxiety disorder was in 2 times (c2=13.08, p<0.0001) less common in patients with chronic migraine than in comorbid patients. The total number of patients with anxiety disorders in patients with chronic migraine on the background of abdominal obesity was twice folds higher (c2=20.93, p=0.00001) than in 1st group patients.

Conclusions: the presence of concomitant abdominal obesity in patients with chronic migrane, not only increases the total number of anxiety disorders, but also affects their structure. Therefore, in addition to basic anti-migraine therapy, non-medicinal therapy in the form of a balanced diet, an individual exercise program and 10-12 sessions of cognitive-behavioral therapy (CBT) should be supplemented for the treatment of such patients.


Hadžiabdic M.O., Mucalo I., Hrabac P., Matić T. , Rahelić D., Božikov V. (2019). Factors predictive of drop-out and weight loss success in weight management of obese patients. J. Hum. Nutr. Diet, 28 Suppl 2, 24-32.

Kovac Blaz M., Svab I. (2020). A multidisciplinary approach to treating obesity in a community health centre. Zdr.Varst., 54(4), 252-258,

Miller B. M.L., Brennan L. (2019). Measuring and reporting attrition from obesity treatment programs: a call to action!. Obes. Res. Clin. Pract., 9, 187-202.

NCD Risk Factor Collaboration (NCD-RisC). (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population- based measurement studies in 128·9 million children, adolescents, and adults. Lancet, 390, 2627-42.

Agarwal А., Ioannidis J. P. A. (2019). PREDIMED trial of Mediterranean diet: retracted, republished, still trusted? BMJ, 364, l341 (Published 7 February 2019).

Burgess E., Hassmén P., Pumpa K. L. (2020). Determinants of adherence to lifestyle intervention in adults with obesity: a systematic review. Clin. Obes., 7(3), 123-135.

Voloshyn, P. V., Maruta, N. O. (2019). Stratehiia okhorony psykhichnoho zdorovia naselennia Ukrainy: suchasni mozhlyvosti ta pereshkody[Strategies to Protect the Mental Health of the Ukrainian Population: Modern Possibilities and Pereskodi]. Ukrainian visnik of psychoneurolonia, 23, 1(82), 5-11.

WHO, Mental health atlas (2020). Retrieved from:

WHO, Mental health: strengthening our response (2018). Retrieved from: response.

WHO, Mental disorders (2019). Retrieved from: disorders.

Brown, G. W. (2020). Psychosocial origins of migraine and anxiety disorders. In: Diagnostic issues in migraine and generalized anxiety disorder, 303-31.

Meeks, Th, Vahia, I, Lavretsky, H et al. (2021). A tune in «A minor» can «B major»: a review of epidemiology, illness course, and public health implications of subthreshold depression and migraine in older adults. J Affect Disord March, 129 (1-3), 126-42.

McGrath, P. J., Miller, J. M. (2020). Co-occurring anxiety and migraine: concept, significance, and treatment implications. In: Anxietyn Disorders. Theory, Research, and Clinical Perspectives, 90-102.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.